Home  ›  Taeniopygia Guttata Ubiquitin-conjugating Enzyme E2q Family Member 1 (Ube2q1), Partial Mrna

Taeniopygia Guttata Ubiquitin-conjugating Enzyme E2q Family Member 1 (Ube2q1), Partial Mrna

Written By Wednesday, 9 March 2022 Add Comment Edit

Promoters and enhancers for UBE2QL1 Gene

GeneHancers around UBE2QL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBE2QL1

Genomic Locations for UBE2QL1 Cistron

Latest Assembly

chr5:half-dozen,437,347-half-dozen,496,723
(GRCh38/hg38)
Size:
59,377 bases
Orientation:
Plus strand

Previous Assembly

chr5:6,448,972-6,496,836
(GRCh37/hg19 by Entrez Gene)
Size:
47,865 bases
Orientation:
Plus strand

chr5:6,448,736-6,495,022
(GRCh37/hg19 past Ensembl)
Size:
46,287 bases
Orientation:
Plus strand

Genomic View for UBE2QL1 Gene

Molecular function for UBE2QL1 Cistron

UniProtKB/Swiss-Prot Function:
Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.
  • U2QL1_HUMAN,A1L167
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-Fifty-cysteine + [E2 ubiquitin-conjugating enzyme]-Fifty-cysteine = [E1 ubiquitin-activating enzyme]-50-cysteine + South-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-Fifty-cysteine.; EC=ii.3.2.23; Prove={ECO:0000255|PROSITE-ProRule:PRU00388};.
  • U2QL1_HUMAN,A1L167

Phenotypes for UBE2QL1 Factor

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miRNA for UBE2QL1 Gene

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No information available for Human Phenotype Ontology , Animate being Models , Transcription Cistron Targets and HOMER Transcription for UBE2QL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2QL1 Factor

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 i ii three 4 five Confidence

COMPARTMENTS Subcellular localization image for UBE2QL1 gene

Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2
mitochondrion 1
lysosome 1
extracellular 0

Pathways by source for UBE2QL1 Gene

UniProtKB/Swiss-Prot A1L167-U2QL1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Additional Pathway Information for UBE2QL1 Gene

  • Pathway Eatables: A1L167

Interacting Proteins for UBE2QL1 Factor

GO ID Qualified GO term Bear witness PubMed IDs
GO:0000209 involved_in protein polyubiquitination IBA 21873635
GO:0016567 protein ubiquitination IEA --

No data available for SIGNOR curated interactions for UBE2QL1 Gene

Proper noun Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
  • MalaCards
  • Medline Plus
 14000-31-eight
  • 1023

mRNA/cDNA for UBE2QL1 Gene

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Relevant External Links for UBE2QL1 Gene

mRNA expression by BioGPS for UBE2QL1 Gene mRNA expression by GTEx for UBE2QL1 Gene

  • Centre (Sensory Organs)
    • GABAergic Amacrine Cells Inner Nuclear Layer
  • Neurons
    • GABAergic Amacrine Cells Inner Nuclear Layer
  • Limb (Muscoskeletal Organisation)
    • Limb Musculus Progenitor Cells Forelimb Myotome
  • Skeletal Muscle (Muscoskeletal System)
    • Limb Muscle Progenitor Cells Forelimb Myotome
  • Epiblast (Early Embryonic Tissues)
    • Intraembryonic Epiblast Cells Epiblast

This gene is overexpressed in Muscle - Skeletal (x6.5), Brain - Cortex (x6.3), Encephalon - Frontal Cortex (BA9) (x5.7), Encephalon - Cerebellar Hemisphere (x4.v), Brain - Anterior cingulate cortex (BA24) (x4.4), and Brain - Cerebellum (x4.2).

  • Nervous organisation (2.8)
  • Expressed in frontal cortex and 195 other tissues.

No data bachelor for Protein differential expression in normal tissues , Protein expression , Poly peptide tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2QL1 Cistron

This gene was present in the common ancestor of animals.

Species where no ortholog for UBE2QL1 was constitute in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Bakery'south yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Craven (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • East. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Light-green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pino (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for UBE2QL1 Gene

  • UBE2Q1
  • GTAP
  • UBE2Q2

Additional Variant Information for UBE2QL1 Factor

Human Factor Mutation Database (HGMD)
UBE2QL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2QL1
Leiden Open Variation Database (LOVD)
UBE2QL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBE2QL1 Gene

- aristocracy association - COSMIC cancer census association via MalaCards

  • Notation=A chromosomal aberration involving UBE2QL1 has been plant in a sporadic example of renal prison cell carcinoma (RCC). Translocation t(5;19)(p15.3;q12). No cistron is disrupted by the chromosome 19 breakpoint. {ECO:0000269 PubMed:24000165}.

Additional Disease Data for UBE2QL1

No data bachelor for Genatlas for UBE2QL1 Gene

  1. UBE2QL1 is disrupted by a ramble translocation associated with renal tumor predisposition and is a novel candidate renal tumor suppressor cistron. (PMID: 24000165) Wake NC … Woodward ER (Homo mutation 2013) two 3 iv
  2. The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal harm. (PMID: 31432621) Koerver Fifty … Meyer H (EMBO reports 2019) 3
  3. Phylogenetic-based propagation of functional annotations inside the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Genome-broad association written report identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. (PMID: 20622878) Remmers EF … Gül A (Nature genetics 2010) 39
  5. Complete sequencing and characterization of 21,243 full-length homo cDNAs. (PMID: 14702039) Ota T … Sugano South (Nature genetics 2004) iii

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Source: https://www.genecards.org/cgi-bin/carddisp.pl?gene=UBE2QL1

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